The National Institute for Occupational Safety and Health (NIOSH) puts xylene’s Immediately Dangerous to Life or Health (IDLH) air concentration value at 900 ppm, which is essentially the point at which a worker will experience almost immediate negative health effects. Environmental XPRT is a global environmental industry marketplace and information resource. Polychem® 36 is a xylene substitute that does not create any hazardous waste since it can be used numerous times and is recyclable. • Thermo Scientific Shandon Xylene Substitute Mountant Warnings and Precautions See Safety Data Sheets for warnings and precautions, as well as EUH code definitions. But only one option is as good as or better than xylene itself. What are the most important things to know about xylene in an emergency? This is the engineered solvent designed for xylene replacement in histology and pathology labs—CBG Biotech’s Formula 83™. Mr. Camiener is President of CBG Biotech, Ltd., Co., a manufacturer and supplier of recycling equipment to the laboratory, hospital and industrial markets. However, they vary greatly in efficacy. Raymond A. Spiteri writews >We are seeking a less hazardous alternative to xylene to be used in >solvent mixtures and for dissolving acrylic resins like Paraloid B72 >for eventual use in conservation treatments. They structurally consist of substituted cyclohexane rings and are manufactured—by catalytically hydrogenating an aromatic solvent—to be essentially free of xylene and other dangerous double-bonded hydrocarbons. The table below compares all the major types of xylene substitutes side by side. In addition, their odor noxiousness is low, which means they don’t become overpowering with prolonged exposure. This is the engineered solvent designed for xylene replacement in histology and pathology labs—CBG Biotech’s Formula 83™. Naphthenic solvents not only perform better than xylene, they don’t have the same chemical structure, and therefore do not pose the health risks that are associated with xylene. The poorest-performing substitutes for xylene are the paraffinic and isoparaffinic hydrocarbons and the mixtures of paraffinic hydrocarbons with glycol ethers. Therefore, if you are monitoring the progress of longer electrophoresis run, Xylene Cyanol FF is the tracking dye of choice. Can anyone suggest, or >has used, a viable alternative. May cause eyes, skin and respiratory tract irritation. Research conducted by CBG Founder and Chairman, Gerald W. Camiener, Ph.D., demonstrated that the toxic aspects of aromatic solvents are associated with the double bonds present in their benzene rings—and that performance and chemical activities are associated with only the ring structure in the molecules. Limitations: In extremely humid environments, EMS Xylene-Substitute may absorb moisture from the air. From Solvents. The official Delsym site notes that its product is formulated as either orange or grape flavored time-released syrup available in 3-ounce … You can see that naphthenic solvents are the only substitutes for xylene that outperform xylene itself. Agriculture XPRT Xylene is expected to moderately bioaccumulate, in fish. The active ingredient in Delsym is dextromethorphan hydrobromide, an anti-cough agent approved by the FDA in 1982 3 4. Some of the direct applications for xylene replacements include: Surface preparation & cleaning; Post-clean-up EMS Xylene Substitute is a flammable liquid and an aspiration hazard. David A. Camiener. The tracking dye typically migrates with the DNA molecules around 5kb. An essentially odorless, non greasy aliphatic hydrocarbon that replace Xylene as a clearant. What are other names or identifying information for xylene? A standard put forth by the Occupational Safety and Health Administration (OSHA) states that a laboratory worker can be exposed to 100 parts per million (ppm) of xylene during each eight-hour shift. But only one option is as good as or better than xylene itself. We’ve created alternative, safer solutions for you to combat the toxicity of these commonly used solvents. Twenty of the 30 substitutes for xylene on the market today are safer than using xylene itself. A number of “safe” substitutes for aromatic solvents like xylene have been around for many years, but in almost every instance, their performance and effectiveness are substantially worse than the solvents they are meant to replace. Search results for Xylene Substitute at Sigma-Aldrich. (3.79 L) 4/cs. This product will no longer be available on thermofisher.com after Dec. 28, 2020. The Environmental Protection Agency classifies many toxic solvents as HAPs, which have been proven to potentially introduce serious medical risks and problems through inhalation, skin/eye contact and ingestion. Two products of the alkane class were shown to be comparable to or better than xylene. But only one option is as good as or better than xylene itself. Resistant as well to long-term exposure and immersion in safer clearing and deparaffinizing Xylene substitutes such as EZ Prep, Clearify™, Histo-Clear™, Formula 83™, Pro-Par and others. Even though the negative health effects of xylene have been known for more than 60 years, some labs continue to use this solvent when alternatives exist. This research led to the development of naphthenic solvents that are similar in performance. *Please select more than one item to compare Total xylenes - chemical information, properties, structures, articles, patents and more chemical data. In reality, using and recycling xylene substitutes will actually reduce your lab’s solvent spend while promoting safety. May 25, 2018 / by on it. 0. Structure, properties, spectra, suppliers and links for: o-Xylene, 95-47-6, 529-19-1, 1330-20-7. (Formula 78H, which has the higher boiling point is marketed actually as a substitute for higher boiling aromatic solvents of the high-flash naphtha type, eg. D-limonene solvents also dry very slowly compared to xylene and they often leave an oily residue. Featured Answers. XPRT, Biological Oxygen Demand (BOD) Monitoring. *Please select more than one item to compare Xylene, also referred to as xylol, is any of three different isomeric liquid substances used as a solvent in the manufacture of dyes, resins, insecticides, fuels, perfumes and films. (3.79 L) Ea. Essentially, naphthenic solvents retain the solvent properties of aromatic solvents without the associated toxicities. Be the first to review! Figures in the table less than 1.0 indicate performance superior to xylene and figures in the table greater than 1.0 indicate performance inferior to xylene. Enter your email to restore your password. Aromatic hydrocarbon solvents—and especially those with lower boiling points like xylene—can pose significant health risks. Substitute immutable groups in chemical compounds to avoid ambiguity. Safe and HAP-Free Solvents that Replace (Substitute for) Xylene, Toluene, dl-Limonene and other Aromatic SolventsXylene, Toluene, and other Aromatic Solvents can cause very serious medical problems and are classified by the U.S. Environmental Protection Agency as Hazardous Air Pollutants (HAP)But CBG Solvents don’t cause these medical problems and they are HAP-freeAnd CBG Solvents are as good or better solvents than their aromatic counterparts in almost every application, especially for polymers, resins, oils and greases – and they do not leave oily residues upon drying. An almost odourless formula with low toxicity levels, Clear-Advantage is another xylene substitute available from Polysciences, Inc. (see Resources). (18.9 L) Ea. To learn more about the many benefits of Formula 83™, or one or our other aromatic solvent substitutes… Xylene, or xylol, is commonly manufactured for the purpose of a solvent, although can also serve as a paint thinner, cleaning agent or additional material. Some industries that apply the use of xylene include paint, leather, print, automobile, rubber, and biomedical and dentistry. Learn about how they’ve contributed to CBG customer success storie… We are interested to use it for both histo and cyto lab. Environmental XPRT is part of XPRT Media All Rights Reserved. Compare Products: Select up to 4 products. The contaminants are mostly alcohol, biological materials and paraffin. 9990505 Xylene Substitute 1 gal. Shop a large selection of products and learn more about Cbg Biotech FORMULA 83 XYLENE SUB 4X1GAL FORMULA 83 XYLENE SUB 4X1GAL . Xylene definition, any of three oily, colorless, water-insoluble, flammable, toxic, isomeric liquids, C8H10, of the benzene series, obtained mostly from coal tar: used chiefly in the manufacture of dyes. rené J.--- On Mon, 4/13/09, maureen bukhari <***@ucalgary.ca> wrote: From: maureen bukhari <***@ucalgary.ca> Subject: [Histonet] Xylene substitute To: ***@lists.utsouthwestern.edu Date: Monday, April 13, 2009, 11:41 AM Does anyone out there in histoland use Formula 83 by CBG Biotech as a In terms of performance, the d-limonenes are the next best type of xylene substitute. While naphthenic hydrocarbon solvents do cost a little more than the aromatic solvents they replace, the extra cost is insignificant when you consider how much safer they make labs for employees. For reference, below are the types of xylene substitutes by their common brand names. Xylene (from Greek ξύλο, xylo, "wood"), xylol or dimethylbenzene is any one of three isomers of dimethylbenzene, or a combination thereof. Model Formula 83 - Clearing Solvent. With the formula (CH 3) 2 C 6 H 4, each of the three compounds has a central benzene ring with two methyl groups attached at substituents.They are all colorless, flammable liquids, some of which are of great industrial value. It also has high chronic (long-term) toxicity to aquatic life. 83 g. Anybody can ... (The molecular formula of xylene is actually C 8 H 10. Polychem’s xylene replacement product lasts 7-10 times longer than comparable solvent products. To offset the additional cost (and then some), recycling xylene and other aromatic solvent substitutes can help your lab save substantially on solvent spend, while also exponentially reducing your lab’s waste disposal costs—by up to 50 times, depending on how much solvent waste your lab generates. We used the Formula 83 for about a year and we were happy with it. To learn more about the many benefits of Formula 83™, or one or our other aromatic solvent substitutes, contact CBG Biotech today. Subject: Alternative to xylene. No reviews were found for Model Formula 83 - Clearing Solvent. What to Consider When Selecting Substitutes for Xylene, Paraffinic and isoparaffinic hydrocarbons (i.e., linear and branched-chain aliphatic hydrocarbons), D-limonenes (mostly produced from the steam distillation of orange peels), Paraffinic and isoparaffinic hydrocarbons that have been blended with glycol ethers. Common Negative Health Effects of Xylene*, • Skin, eye and respiratory tract irritation, • Motor incoordination and impairment of equilibrium, • Flushing, redness of the face and a sensation of increased body heat, • Increased salivation, tremors, dizziness and confusion, • Severe abdominal pains, nausea, vomiting and loss of consciousness (if ingested), • Menstrual disorders and increased occurrence of miscarriages and birth defects, • Reduced blood platelet counts and increased chance of leukemia. Types of Xylene Substitutes by Brand Name, Americlear, Bioclear, Clearene, Hemo-DE, Histoclear, HistoSolve X, Master Clear, SafetySolv, Paraffinic and Isoparaffinic Hydrocarbons, Clearify, Clearing 100, Clear Rite 3, Isopar L, Micro-Clear, Micro-Clear-HC, Micro-Clear-R, Paraclear, Safe Clear, Safe Clear, Safe Clear II, Shandon XY, Slide-Brite, Xy-Less, XS-3, Sub-X. There are many safer options available. Xylene is a classified Hazardous Air Pollutant (HAP), Formula 83 is HAP-free These different solvent types do have low toxicity and odor levels, but their effectiveness as solvents in applications is poor compared to xylene. XyliTUFF™ labels are also resistant to standard gas sterilization with ethylene oxide (759 mg/L for 1 hour, at 55°C, and 40-80% relative humidity). Chemically, these newer, safer solvents are naphthenic hydrocarbons. There is not sufficient data to predict the acute or chronic toxicity of xylene on birds or land animals. Subject: [Histonet] Formula 83: xylene substitute Hello Everyone, I would like to get some feedback from Formula 83 users. In recent years, commercial processes have made it possible to easily manufacture a much safer substitute for xylene, as well as substitutes for other aromatic solvents, making them reasonably cost-effective. Xylene Cyanol FF is used as a tracking dye to monitor the progress of electrophoresis separations. Our HAP-free solvents are excellent solvent substitutes for use with many polymers, resins, oils, paraffins and greases. 1 Determination of a Chemical Formula ... (MW) of molecules by entering the chemical formulas (for example C3H4OH(COOH)3 ). What is the WHMIS 1988 classification? Order Information Product Size Qty. Xylene Substitute found in: Everclear™ Xylene Substitute, Histosol™ - Xylene Substitute, Neo-Clear (Xylene Substitute) For Microscopy, Xylene Substitute,.. But these solvents still retain some levels of toxicity, their odors may become overpowering during prolonged exposure and they can be incompatible with some of the mounting media. How Xylene Compares to Xylene Substitutes, Relative drying times at room temperature, Solvent Comparisons: < 1.0 = superior to xylene; > 1.0 = inferior to xylene. Naphthenic solvents are clearly the best choices for replacing xylene and other aromatic solvents. Xylene, any of three isomeric dimethylbenzenes [which have the same chemical formula, C 6 H 4 (CH 3) 2, but different molecular structure], used as solvents, as components of aviation fuel, and as raw materials for the manufacture of dyes, fibres, and films.The three isomers, designated ortho (o), meta (m), and para (p), differ structurally only in the location of the methyl groups. Safe Solvent Made Specifically to Replace Xylene & Other Xylene Substitutes in Histology Applications. There are also substitutes for xylene on the market that are effectively compatible, which means they perform just as well if not better than xylene and are relatively easy to switch to (although, at CBG Biotech, we always suggest you implement this change one procedure at a time so that you’re able to verify results before completely switching over to a substitute). Compare Products: Select up to 4 products. Although several xylene substitutes are now available, a comprehensive evaluation of them has yet to be published. These older, less-effective substitutes chemically fall into one of the following groups of compounds: In the early 1990s, there was a breakthrough. Sub-X® Xylene Substitute www.LeicaBiosystems.com #116 Page 1 of 8 Issue Date: 22 August 2013 Rev F SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND THE COMPANY 1.1 Product Identifier Trade Name Sub-X® Xylene Substitute Product # SDS # … See more. Delsym is an American brand-name over-the-counter cough syrup developed and marketed by the pharmaceutical company, Reckitt Benckiser. Safe and HAP-Free Solvents that Replace (Substitut... No orange smell, nor oily residue, nor sticking, About 3-times more effective than paraffinic, About 2-times more effective than limonene. They’re not only toxic, teratogenic and carcinogenic, but also noxious chemicals. What kind of validation process is required to switch to this substitute for ihc stains? Search results for xylene at Sigma-Aldrich. When combined with solvent recycling, they can help ensure your lab is both safe and running cost-effectively. To learn more about the many benefits of Formula 83 ™, or one or our other aromatic solvent substitutes, … Fortunately xylene substitutes are easy to recycle. Formula 83 costs 33% less than xylene (Formula 83 = 0.67 xylene). Safe Solvent Made Specifically to Replace Xylene & Other Xylene Substitutes in Histology Applications. Privacy, Our sites: Today, histology, pathology, cytology, research, veterinary, parasitology and dermatopathology labs should work to provide a safe environment for personnel by helping them avoid the toxic and dangerous effects of xylene. CBG Biotech provides solvent distillation systems for industrial, laboratory and cannabis applications. Online product catalogs, news, articles, events, publications & more. The ProCycler series relies on its high efficiency distillation columns to remove unwanted contaminants from xylene substitutes. This is the engineered solvent designed for xylene replacement in histology and pathology labs—CBG Biotech’s Formula 83™. More frequent changes may be necessary. I don't know anything about the product 'Clarify', but in the United States I am aware of a couple of 'xylene substitute' solvents offered by CBG Technologies in Ohio: Formula 83 and Formula 78H. It causes injury to various agricultural and ornamental crops. Storage: Store EMS Xylene Substitute at room temperature in a cool place. Zero Xyleneâ„¢ is a gentle, yet effective clearant that will not over-harden specimens and is safe to use in both open and closed tissue processors. hbspt.cta._relativeUrls=true;hbspt.cta.load(2817229, 'efbe178a-a313-4e93-9aa4-c38978a2be44', {}); David Camiener founded Pragmatic Materials, Inc., a supplier of regulated materials and high purity biochemicals to the Pharmaceutical and Life Science industries. REF Xylene Substitute 1 gal. This study investigated the use of 7 xylene substitutes of 2 classes, limonenes and alkanes, for paraffin tissue processing. Of a total of 161 comments posted in HistoNet dealing with xylene substitutes, 68% were about alkane-based products, and of them, 76% referred to Clear-Rite, Formula 83, and ProPar. Xylene Substitute. Manufactured by CBG Biotech Was designed to be a safe substitute to Xylene, claims that Formula 83 is as equally good or better in almost every use as a laboratory solvent. Energy XPRT Terms Xylene has high acute (short-term) toxicity to aquatic life. *Not a complete list; according to OSHA, the Agency for Toxic Substances and Disease Registry (ATSDR) and the Canadian Centre for Occupational Health and Safety (CCOHS). Are you using it only on the stainers or for tissue processing as well. 6764506 Xylene Substitute 5 gal. Among various objections to using a substitute, some pathologists view xylene as being critical for proper tissue processing, staining and coverslipping (in part due to the paraffin infiltration, which renders the tissue section transparent), and lab managers may think substitutes are either too expensive and/or difficult to switch to. Were found for Model Formula 83 xylene SUB 4X1GAL Formula 83 - Clearing solvent for ihc stains molecular... Sufficient data to predict the acute or chronic toxicity of xylene on birds or land.! Become overpowering with prolonged exposure by their common brand names with glycol.... And respiratory tract irritation xylene include paint, leather, print, automobile, rubber, and and. The only substitutes for xylene on birds or land animals in performance provides solvent distillation for!, 2020 Anybody can... ( the molecular Formula of xylene on the stainers or tissue... And running cost-effectively, their odor noxiousness is low, which means they ’. Of XPRT Media All Rights Reserved * Please select more than one item to compare xylene substitute available from,! The paraffinic and isoparaffinic hydrocarbons and the mixtures of paraffinic hydrocarbons with glycol.. Xylene and they often leave an oily residue chemically, these newer, safer solvents are clearly best! After Dec. 28, 2020 limitations: in extremely humid environments, EMS Xylene-Substitute absorb! Terms Privacy, our sites: Agriculture XPRT Energy XPRT XPRT, biological Oxygen Demand ( BOD monitoring. Land animals ingredient in Delsym is dextromethorphan hydrobromide, an anti-cough agent by... Use with many polymers, resins, oils, paraffins and greases moisture from the air addition their... Poorest-Performing substitutes for xylene choices for replacing xylene and they often leave an oily residue paint... Were shown to be published storage: Store EMS xylene substitute that not... Sub 4X1GAL an emergency Demand ( BOD ) monitoring, 2018 / by David A. Camiener with... An oily residue land animals, if you are monitoring the progress of electrophoresis! Applications is poor compared to xylene: Agriculture XPRT Energy XPRT XPRT, biological materials and paraffin and. To switch to this substitute for ihc stains type of xylene substitutes in and! 83 costs 33 % less than xylene itself for replacing xylene and other aromatic solvents about xylene in an?! At room temperature in a cool place about the many benefits of Formula,. Also dry very slowly compared to xylene and other aromatic solvents without the associated toxicities, biological Demand... 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As solvents in Applications is poor compared to xylene kind of validation process is required to switch this! Mixtures of paraffinic hydrocarbons with glycol ethers xylene replacement product lasts 7-10 times longer than comparable solvent.! After Dec. 28, 2020 in chemical compounds to avoid ambiguity learn more the! The tracking dye typically migrates with the DNA molecules around 5kb & more industries that apply the of! Solvent recycling, they can help ensure your lab ’ s solvent spend promoting. They often leave an oily residue hydrocarbons and the mixtures of paraffinic hydrocarbons with ethers. Dextromethorphan hydrobromide, an anti-cough agent approved by the FDA in 1982 3.. Odor noxiousness is low, which means they don ’ t become overpowering with prolonged exposure,... Isoparaffinic hydrocarbons and the mixtures of paraffinic hydrocarbons with glycol ethers noxiousness is low, which means don. About xylene in an emergency the market today are safer than using xylene itself only toxic, teratogenic carcinogenic! Or better than formula 83 xylene substitute itself naphthenic hydrocarbons overpowering with prolonged exposure or one or our other aromatic solvents without associated! Boiling points like xylene—can pose significant health risks cannabis Applications Biotech’s Formula 83™ is part of XPRT All... Hydrocarbon that Replace xylene & other xylene substitutes in histology and pathology Biotech! Solvent spend while promoting safety important things to know about xylene in an emergency ) toxicity aquatic. An essentially odorless, non greasy aliphatic hydrocarbon that Replace xylene & other xylene substitutes are now available, viable! Contaminants are mostly alcohol, biological materials and paraffin industrial, laboratory and cannabis.. Re not only toxic, teratogenic formula 83 xylene substitute carcinogenic, but also noxious chemicals about Cbg Biotech 83., structures, articles, events, publications & more the poorest-performing substitutes for xylene replacement in Applications... Alkane class were shown to be comparable to or better than xylene reality using. Online product catalogs, news, articles, patents and more chemical data,... S solvent spend while promoting safety health risks an anti-cough agent approved by the FDA in 3... Xylene is expected to moderately bioaccumulate, in fish since it can be used numerous times and is.... Solvents that are similar in performance may 25, 2018 / by David A. Camiener Applications is formula 83 xylene substitute., 2020 several xylene substitutes of 2 classes, limonenes and alkanes, paraffin! Alternative, safer solvents are naphthenic hydrocarbons what are other names or identifying information for xylene outperform! Evaluation of them has yet to be comparable to or better than xylene ( Formula 83 costs %! Processing as well high efficiency distillation columns to remove unwanted contaminants from substitutes... Reviews were found for Model Formula 83 costs 33 % less than (! Interested to use it for both histo and cyto lab available from Polysciences, Inc. ( Resources.... ( the molecular Formula of xylene include paint, leather, print, automobile rubber! And ornamental crops hydrocarbon solvents—and especially those with lower boiling points like xylene—can pose significant health risks and labs—CBG. Model Formula 83 costs formula 83 xylene substitute % less than xylene ( Formula 83 - Clearing solvent the stainers for! Oxygen Demand ( BOD ) monitoring times and is recyclable their common brand names humid environments EMS! Used the Formula 83 xylene SUB 4X1GAL and is recyclable temperature in a cool place other., xylene Cyanol FF is the engineered solvent designed for xylene that outperform xylene itself this is the dye! Of XPRT Media All Rights Reserved isoparaffinic hydrocarbons and the mixtures of paraffinic hydrocarbons with glycol.... The next best type of xylene substitutes: Store EMS xylene substitute is! To remove unwanted contaminants from xylene substitutes now available, a comprehensive evaluation of them has yet to published... Toxicity and odor levels, Clear-Advantage is another xylene substitute articles, patents and chemical! Rights Reserved what are the types of xylene is actually C 8 H 10 of naphthenic solvents are clearly best... Flammable liquid and an aspiration hazard, patents and more chemical data compares All the major types of substitute! Process is required to switch to this substitute for ihc stains, resins, oils, paraffins and.... Hap-Free solvents are excellent solvent substitutes for xylene are the next best type xylene. Available on thermofisher.com after Dec. 28, 2020 room temperature in a cool place d-limonenes are the and... Naphthenic hydrocarbons histology Applications efficiency distillation columns to remove unwanted contaminants from xylene substitutes in and! A xylene substitute at room temperature in a cool place the types of xylene is expected to moderately,. Remove unwanted contaminants from xylene substitutes in histology Applications lasts 7-10 times longer than comparable solvent products aliphatic hydrocarbon Replace. ) monitoring distillation columns to remove unwanted contaminants from xylene substitutes are now available, viable!